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Methodology Poster Abstracts
P099. Imaging the sensitivity of [123I]5-IA-85380 to increases in acetylcholine at the beta2-nicotinic acetylcholine receptors: physostigmine studies in human subjects
Irina Esterlis1, Jonas Hannestad1, Frederic Bois1, John Seibyl2, Marc Laruelle1, Richard E. Carson3 and Kelly Cosgrove4
1Yale University Department of Psychiatry, New Haven, Connecticut, USA; 2Institute for Neurodegenerative Disorders New Haven, Connecticut, USA; 3Yale University Department of Radiology, New Haven, Connecticut, USA; 4Yale University Departments of Psychiatry and Radiology, New Haven, Connecticut, USA
Background: Competition between neurotransmitter and radioligands has provided a very useful method to assess synaptic changes in dopamine, but this approach has been slow to extend to other neurotransmitter system. Previously, Fujita and colleagues showed that the high affinity beta2-nicotinic acetylcholine receptor (β2-nAChR) radioligand [123I]5-IA-85380 (5-IA) may be sensitive to extracellular increases in ACh in baboons; 1 however, such an examination in humans has lagged. Given that acetylcholine is one of the major neurotransmitters in the brain and has been implicated in the psychiatric and medical illnesses, we developed a paradigm
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EA6134 / DREAMseq
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