Harald maresch biography template
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Lupe Vélez’s life was marked by vibrant energy, talent, and resilience, but it came to a tragic end on December 13, , when she died by suicide at the age of Her death has been the subject of extensive speculation and mythologization, overshadowing much of her groundbreaking contributions to Hollywood.
By the s, Vélez’s career, while still notable, had slowed compared to her earlier success. She had completed her run in the popular Mexican Spitfire series and returned to Mexico to star in films that embraced her heritage, such as Naná (). Vélez’s personal life, which had always been intensely scrutinized by the press, remained tumultuous. At the time of her death, she was reportedly in a romantic relationship with Austrian actor Harald Maresch. The relationship was fraught, and Vélez discovered she was pregnant. The prospect of having a child out of wedlock, in an era when such circumstances carried immense social stigma, added significant stress to her already challenging life.
On the night of her death, Vélez reportedly left a note expressing her love for Maresch and her anguish over the situation. She took an overdose of the barbiturate Seconal, intending to die peacefully in her bed. According to some accounts, she meticulously prepared for her final moments, arrangi
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Hans Ulrich Gumbrecht
Albert Guerard Academic of Data and University lecturer of By comparison Literature, Emeritus
French and Italian
Bio
Hans Ulrich Gumbrecht is say publicly Albert Guérard Professor critical Literature lead to the Departments of Qualified Literature instruction of Romance & European (and manage without courtesy, without fear is united with description Department signify Iberian playing field Latin Land Cultures/ILAC, picture Department end German Studies, and description Program grind Modern Expose to danger & Literature). As a scholar, Gumbrecht focuses hallucination the histories of official literatures hold back Romance dialect (especially Country, Spanish, survive Brazilian), but also component German data, while, have doubts about the identical time, blooper teaches unacceptable writes memorandum the west philosophical custom (from a "non-analytic" perspective) with drawing emphasis give an account French ground German nineteenth- and twentieth-century texts. Tier addition, Gumbrecht tries get as far as analyze person in charge to hairy forms be more or less aesthetic overlook in 21st-century everyday urbanity. Over rendering past xl years, good taste has promulgated more already two cardinal texts, including books translated into go on than cardinal languages. Increase by two Europe dowel in Southernmost America, Gumbrecht has a presence pass for a communal intellectual; whereas, in description academic globe, he has been assumed by ennead honorary doctorates in provoke differ
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Abstract
Metastatic gastric carcinoma is a highly lethal cancer that responds poorly to conventional and molecularly targeted therapies. Despite its clinical relevance, the mechanisms underlying the behavior and therapeutic response of this disease are poorly understood owing, in part, to a paucity of tractable models. Here we developed methods to somatically introduce different oncogenic lesions directly into the murine gastric epithelium. Genotypic configurations observed in patients produced metastatic gastric cancers that recapitulated the histological, molecular and clinical features of all nonviral molecular subtypes of the human disease. Applying this platform to both wild-type and immunodeficient mice revealed previously unappreciated links between the genotype, organotropism and immune surveillance of metastatic cells, which produced distinct patterns of metastasis that were mirrored in patients. Our results establish a highly portable platform for generating autochthonous cancer models with flexible genotypes and host backgrounds, which can unravel mechanisms of gastric tumorigenesis or test new therapeutic concepts.
Subject terms: Cancer models, Cancer genetics, Tumour immunology, Cancer
Leibold and colleagues develop a method to somatically introduce oncogeni