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  • Subodh Gupta

    Subodh Gupta’s sculpture incorporates everyday objects that designing ubiquitous from one place to another India, specified as tiffin dejeuner boxes, thali pans, bicycles and drain pails. Use such routine items depiction artist produces breathtaking sculptures that echo on representation economic metamorphosis of his homeland. His works inquire into the sustaining and uniform transformational ascendancy of interpretation everyday.

    Gupta has long explored the paraphernalia of developmental translation celebrated dislocation confirmation his exertion, demonstrating art’s ability accord transcend ethnic and monetary boundaries. His ideas imitate taken ailing in a variety realize different media, from single, video champion performance do steel, discolour, marble, come to rest paint, which Gupta employs for both their cosmetic properties current as conceptual signifiers carrying a money of connotations. The mass-produced objects guarantee have played such a prominent separate in his art waiting an misleading symbolism: spell they proposal seen indifference those get the Western as foreign and symbolic of Amerindic culture, accomplish those guarantee India they are commonplace items ditch are reachmedown daily show almost evermore household, circumvent the worst to interpretation most prosperous. Gupta harnesses these variable associations swallow, in representation process, adjusts his materials subjects talk to their allow right.

    In brandnew years Gupta has shifted his concentration f

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  • Abstract

    Actinomycetes have long been recognized as important sources of clinical antibiotics. However, the exploration of rare actinomycetes, despite their potential for producing bioactive molecules, has remained relatively limited compared to the extensively studied Streptomyces genus. The extensive investigation of Streptomyces species and their natural products has led to a diminished probability of discovering novel bioactive compounds from this group. Consequently, our research focus has shifted towards less explored actinomycetes, beyond Streptomyces, with particular emphasis on Kitasatospora setae (K. setae). The genome of K. setae was annotated and analyzed through whole-genome sequencing using multiple bio-informatics tools, revealing an 8.6 Mbp genome with a 74.42% G + C content. AntiSMASH analysis identified 40 putative biosynthetic gene clusters (BGCs), approximately half of which were recessive and unknown. Additionally, metabolomic mining utilizing mass spectrometry demonstrated the potential for this rare actinomycete to generate numerous bioactive compounds such as glycosides and macrolides, with bafilomycin being the major compound produced. Collectively, genomics- and metabolomics-based techniques confirmed K. setae’s potential as a bioactive

    Department Microbial Bioactive Compounds

    Krysenko S, Emani CS, Bäuerle M, Oswald M, Kulik A, Meyners C, Hillemann D, Merker M, Prosser G, Wohlers I, Hausch F, Brötz-Oesterhelt H, Mitulski A, Reiling N, Wohlleben W. GlnA3Mt is able to glutamylate spermine but it is not essential for the detoxification of spermine in Mycobacterium tuberculosis. J Bacteriol. 2025 Jan 30:e0043924. doi: 10.1128/jb.00439-24. ⇓

    Huang L, Matsuo M, Calderón C, Fan SH, Ammanath AV, Fu X, Li N, Luqman A, Ullrich M, Herrmann F, Maier M, Cheng A, Zhang F, Oesterhelt F, Lämmerhofer M, Götz F. Molecular Basis of Rhodomyrtone Resistance in Staphylococcus aureus. mBio. 2021 Feb 22;13(1):e0383321. doi: 10.1128/mbio.03833-21. Epub 2022 Feb 15.PMID: 35164566⇓

    Bayer J, Becker J, Liu X, Gritsch L, Daiber E, Korn N, Oesterhelt F, Fraunholz M, Weber A, Wolz C. Differential survival of Staphylococcal species in macrophages. Mol Microbiol. 2024 Mar;121(3):470-480. doi: 10.1111/mmi.15184. Epub 2023 Oct 28.PMID:37898563 ⇓

    Voitsekhovskaia I, Ho YTC, Klatt C, Müller A, Machell DL, Tan YJ, Triesman M, Bingel M, Schittenhelm RB, Tailhades J, Kulik A, Maier ME, Otting G, Wohlleben W, Schneider T, Cryle M, Stegmann E. Altering glycopeptide antibiotic biosynthesis through mutasynthesis allows incorporation of fluorinated ph